Primary Malignant Lymphoma of the Brain: Demonstration of Frequent p16 and p15 Gene Deletions
نویسندگان
چکیده
منابع مشابه
PRIMARY MALIGNANT LYMPHOMA OF THE BREAST
A case of primary malignant non-Hodgkin's lymphoma of the breast is reported. This is the first well-documented case of breast lymphoma in our institution and also in Iran. The diagnosis of primary breast lymphoma requires the presence of lymphomatous infiltration in close ass, tissue in patients with neither previous lymphoma nor concurrent lymphoma in another site. There is no definite cl...
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Both p16 and p15, encoded by the genes located on chromosome 9p21, are inhibitors of cyclin-dependent kinases (CDK4/6) and the upstream regulators of Rb function. In hematopoietic malignancies, deletion of p16/p15 locus has been shown to be highly specific to lymphoid, and more particularly from B-lineage malignancies except multiple myeloma (MM). To investigate whether these genes are inactiva...
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The fact that the p16/INK4a and p15/INK4b genes are frequently inactivated in human malignancies and that p16/INK4a null mice spontaneously develop B-cell lymphomas prompted us to examine the status of both genes in Burkitt's Lymphoma (BL). We found a low frequency of p16/INK4a and p15/INK4b deletions and mutations in BL cell lines and biopsies. However, p16/INK4a exon 1 was methylated in 17 ou...
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چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...
15 صفحه اولThe Prognostic Significance of p16/p14 and p15 Deletions in Adult Acute Lymphoblastic Leukemia
Cytogenetic/molecular abnormalities significantly influence the prognosis of patients with acute leukemia. Recently, two genes, p16 and p15, encoding two cyclin-dependent kinase inhibitor proteins of the INK4 family of Mr 15,000 and 16,000, respectively, have been localized to 9p21. Remarkably, the p16 locus has been found to encode a second protein, p14, known as p19 in mice, with a distinct r...
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ژورنال
عنوان ژورنال: Japanese Journal of Cancer Research
سال: 1996
ISSN: 0910-5050
DOI: 10.1111/j.1349-7006.1996.tb00279.x